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October 19, 2012

Construction work commenced for the biopharmaceutical API manufacturing facility in the Takasaki Plant

Tokyo, Japan, October 19, 2012 --- Kyowa Hakko Kirin Co., Ltd. (Tokyo:4151, President and CEO: Nobuo Hanai, “Kyowa Hakko Kirin”) will commence the construction of the HA4 Plant (biopharmaceutical API manufacturing facility) at the Takasaki Plant in December 2012.

The HA4 Plant will be installed as one of the largest bioreactors for recombinant animal cells (12,000 L bioreactor), as well as a purification facility with a large column. By utilizing the manufacturing technology of biopharmaceutical products cultivated by the company, we will realize a larger scale and stable manufacture and continue to make efforts to provide the market with high-quality pharmaceutical products.

New plant overview
Plant Name HA4 Plant 
Scale Built with reinforced concrete, four-storied, total floor area of approx. 3892 m2
Investment Approx. 6 billion yen 
Purpose Manufacture of biopharmaceutical API 
Schedule The completion is fourth quarter, 2013 (October to December) 
Characteristics (1) The facility complies with GMP in Japan, the US, and the EU.
(2) The facility is equipped with a 12,000 L bioreactor, which is one of the largest of its kind in Japan, as well as a large column compatible with this bioreactor.

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