Sustainability

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For People’s Health and Well-being

The Kyowa Hakko Kirin Group advances its CSV*1 management by capitalizing on its distinctive business foundation. While fulfilling our mission as a pharmaceutical company by discovering innovative new drugs and supplying them on a stable basis, we strive to solve social health-related issues and enhance people’s quality of life (QOL) to contribute to the health and well-being of people around the world.

*1
CSV stands for “Creating Shared Value” and refers to realizing improved corporate value through both the creation of social value and the creation of economic value by addressing social issues.

Providing Health-oriented Customer Value

There are therapeutic areas where no or only insufficiently effective treatment is available and breakthrough drugs are coveted by patients and the medical community. By developing innovative new drugs based on cutting-edge biotechnology, expanding indications and adding new formulations, and offering stable supplies of high-quality drugs, Kyowa Hakko Kirin endeavors to fulfill unmet medical needs around the world.

In the area of research and development, we are making progress in developing global strategic products such as burosumab (KRN23), mogamulizumab (KW-0761) and istradefylline (KW-6002). Notably, burosumab (KRN23), an anti-FGF23 fully human monoclonal antibody, which we have been jointly developing with Ultragenyx Pharmaceutical Inc. as a therapeutic drug for hereditary rickets and osteomalacia, received approval from the U.S. Food and Drug Administration (FDA) in April 2018 and was launched under the brand name Crysvita® in the U.S. market. In February 2018, the drug was also granted conditional approval from the European Commission to be sold as a pharmaceutical product in Europe.

Meanwhile, mogamulizumab (KW-0761), an anti-CCR4 humanized monoclonal antibody, was granted breakthrough therapy designation by the USFDA in 2017. We have also applied for marketing approval of the drug in Europe and the United States.

Addressing Social Needs to Contain Medical Costs

FUJIFILM KYOWA KIRIN BIOLOGICS Co., Ltd. is leveraging its innovative production technology to develop low-cost and high-quality biosimilar products*2 that can be stably supplied in the global market. Biosimilars respond to social needs for containing medical costs, and their markets are expected to expand worldwide.

In May 2017, the application for marketing approval of adalimumab biosimilar (FKB327), a fully human anti-TNFα monoclonal antibody, was accepted in Europe.

In addition, Kyowa Kirin Frontier Co., Ltd. is working to obtain approval for the domestic manufacture of “Authorized version*3” of NESP®, a core product of Kyowa Hakko Kirin.

By harnessing our latest biopharmaceutical manufacturing technology, we intend to ensure stable and efficient delivery of high-quality products with the aim of responding to social needs to contain medical costs.

*2
A biosimilar product is a pharmaceutical with equal or identical quality, safety and efficacy to the original biopharmaceutical approved as a new drug on which it is modeled. Biosimilars are developed, manufactured and marketed by a company different from the manufacturer of the original drug, based on guidelines on biosimilars.
*3
Kyowa Hakko Kirin thinks “Authorized version” is an identical drug to the branded drug in terms of active pharmaceutical ingredients, excipients and manufacturing method and which are manufactured and marketed by a company that receives the rights to exploit the branded drug’s patent from the company that owns the patent.

Contributing to Preventive Medicine and Presymptomatic Healthcare

Anticipation for preventive medicine is becoming heightened, driven by increasing public awareness of the importance of extending healthy life spans in an era of global population aging.

On February 1, 2017, jointly with Hirosaki University, a national university, Kyowa Hakko Bio started offering a joint research course titled Preemptive Nutrition and Laboratory Medicine, aimed at promoting research and development on preemptive nutrition medicine for extending people’s healthy life span. The course focuses on preventive medicine with the aim of developing disease prediction methods using big data on health and disease prevention methods based on predictive factors. By harnessing the big data on health of local regions, we are striving to elucidate the correlation between laboratory data and lifestyle with a focus on nutrition, and to spur the development of new laboratory indices and methods of promoting public awareness*4.

We are also conducting a joint industry-academia-government research project to explore the effects of nutrition improvements on motor functions by exploring the effects of L-citrulline on elderly people and the effects of the combined intake of L-citrulline and L-arginine.*5

Based on research findings on nutrition improvements aimed at enhancing motor functions, we are hoping to develop a new health business to contribute to the health and well-being of people around the world.

*4
*5

Contributing to Enhancing Global Health

“Global health” refers to a field where cooperative and collaborative efforts of the entire international community are required to solve issues exerting impacts on human health on a global scale. The Sustainable Development Goals (SDGs) adopted by the United Nations in 2015 positions global health as an internationally significant issue.

Participating in the Global Health Innovative Technology Fund (GHIT Fund)

Since 2016, Kyowa Hakko Kirin has been participating in the GHIT Fund, a public-private partnership for promoting discovery of new drugs for infectious diseases in developing countries. We will be participating in the second phase of the activity, which will start in fiscal 2018.

A public-private partnership jointly funded by the Government of Japan, Japan’s leading life science companies, the Bill & Melinda Gates Foundation, the Wellcome Trust, and the UN Development Programme (UNDP), the GHIT Fund is the world’s first of its kind to exclusively tackle product development in the global health field.

By endorsing the GHIT Fund’s objective of establishment and activities and by supporting its activities to deliver new drugs to patients with currently untreatable diseases, Kyowa Hakko Kirin aims at contributing to the enhancement of global health.

Notification on participation in GHIT Fund’s second phase (in Japanese only)

Contributing to Solving Health-related Social Issues

The Kyowa Hakko Kirin Group makes donations to foundations and engages in activities to raise awareness on various diseases with the aim of contributing to solving health-related social issues.

Contributing to enhancing medical care and advancing medical and pharmaceutical sciences

Hoping to promote an interest in science among the broader population, we publicly share information on biotechnology and make donations to the Kato Memorial Bioscience Foundation*, which supports the development of the next generation of researchers.

Helping raise awareness on diseases

Employees at our business sites across the world participate with their family members in charity events held to help people better understand certain diseases.

  • Charity marathon in support of pediatric cancer patients (Korea)
  • Charity marathon in support of Parkinson’s disease patients (U.S.A.)
  • Charity walk event in support of leukemia and lymphoma patients (U.S.A.)


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