Therapeutic Antibodies

Mechanisms of action of therapeutic antibody

Therapeutic antibody has 3 typical mechanisms of action.

Neutralizing activity

When ligands such as growth factor bind to their receptors, ligands activate target cells and cause damages.

When therapeutic antibody binds to its target, ligand or receptor, antibody interferes ligand-receptor interaction and prevents undesirable activities.

ADCC activity

ADCC (Antibody-Dependent Cellular Cytotoxicity)

Immune cells such as macrophages and NK cells recognize the antibody bound to the target cell and destroy the target cells such as tumor cells.

CDC activity

CDC (Complement-Dependent Cytotoxicity)
CDC is a reaction in which an antibody bound to its antigen activates reaction cascade of a group of serum proteins called complement system.

CDC is triggered by the binding of complement to the antibody bound to cell surface an antigen.

Activated complement system lyses the target cell.

In addition, therapeutic antibody treat diseases through a variety of mechanisms.